Personality disorders are regarded as conditions that involve a maladaptive personality functioning. Homelessness is a worldly debated phenomenon. The present study aimed to understand the situation of homelessness related to the health sector, instead of considering it only as a social or economic problem. Research was conducted with three different groups, male and female, living in a Metropolitan area of Southeast Brazil, the first composed of 71 homeless people; the second, 74 psychiatric patients; and the third, 250 college students that completed the Personality Disorders Dimensional Inventory (IDTP).